The importance of prolonged binding to antigen-presenting cells for T cell fate decisions

Published in: Immunity (February 2008)

Authors: John J. Engelhardt, Matthew F. Krummel

The parallel lives of angiogenesis and immunosuppression: cancer and other tales

Published in: Nature Reviews Immunology (September 2011)

Authors: Gregory T. Motz, George Coukos

Cancer vaccines: trafficking of tumor-specific T cells to tumor after therapeutic vaccination

Published in: The International Journal of Biochemistry & Cell Biology (August 2014)

Authors: Yared Hailemichael, Willem W. Overwijk

Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors

Published in: Cancer Research (March 1996)

​​Authors: Karolien Castermans, Arjan W. Griffioen

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

Published in: Nature Medicine (January 2008)

​​Authors: Buckanovich et al.

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes

Published in: Cancer Research (February 2011)

​Authors: Palazón et al.

Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion

Published in: Journal of Biological Chemistry (July 2013)

Authors: Vanderslice et al.

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Integrin activator vaccine compositions

Inventors: Darren Woodside, Peter Vanderslice, Upendra Marathi​​

LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade

Published in: The Journal of Clinical Investigation (May 2022)

Authors: Hickman et al.

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Integrin-mediated augmentation of antigenic immunity

Proceedings: The Society for Immunotherapy of Cancer's (SITC) 34th Annual Meeting (2019)


7 Hills Selected Patents

7 Hills Integrin Activators

Tumor blood vessels, a difficult hurdle for infiltrating leukocytes

Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (December 2007)

​​Authors: Karolien Castermans, Arjan W. Griffioen

Potentiating immune checkpoint blockade therapeutic efficacy using a small molecule activator of integrin cell adhesion receptors

Proceedings: American Association for Cancer Research (AACR) Annual Meeting 2019​​

T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy

Published in: Cancer Discovery (May 2014)

​​Authors: Melero et al.

Role of Integrins in T Cell Activation

Regulation of human T lymphocyte coactivation with an alpha4 integrin antagonist peptide

Published in: The Journal of Immunology (May 1997)

​Authors: McIntyre et al.

Immune activators – enhancing cell adhesion to safely improve effectiveness of vaccines & cancer immunotherapies

Published in: Drug Development & Delivery (March 2021)

Authors: Siddhartha De, Peter Vanderslice

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Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment

Published in: Frontiers in Immunology (May 2019)

​Authors: Harjunpää et al.

Publications

7 Hills Poster Presentation Abstracts

Role of Integrins in Tumor Immune Surveillance